I just got the first report in that iTunes 7.4.2.4 breaks rTunes, here we go again Apple, can't you maintain a stable interface for crying out loud. The good news, is I have no problems connecting with the raw source, it's only the compiled version that is having difficulties right now. If you'd like the instructions on installing python and the necessary packages to get rTunes working leave a comment and I'll post them.

Update:

The release of 7.4.2.4 changed the com signature which means the hard-coded com signature in the binary package is out of sync, unfortunately there doesn't  seem to be a better way at this time when it comes to py2exe.

I should have a new version out this evening, I just need to package and test, and I also found a very annoying "bug/design feature" in the http lib which was making rTunes very slow when DNS is being used on a local network, like my home network.